An analysis of the adequacy of the asymmetric carrier model for sugar transport.
نویسندگان
چکیده
In 1972, Lieb, W. R. and Stein, W. D. (Biochim, Biophys. Acta 265, 187-207) in their review of sugar transport in human erythrocytes concluded that the conventional two-state carrier model was inconsistent with the experimental data available at that time. Since then, other papers have appeared which question the validity of the model. In this paper, we give a brief derivation of the equations describing the two-state carrier model, and analyze the predictions of the model in the classical experiments, i.e. zero-trans, infinite-cis, and equilibrium exchange. We show that the estimate of the half saturation constant of 2.8 mM for glucose at the inner face of the human red cell membrane for the infinite-cis procedure reported by Hankin, B.L., Liev, W.R. and Stein, W.D ((1972) Biochim. Biophys. Acta 288, 114-126) is unreliable. We note that all of the other experimental findings are consistent with the asymmetric carrier model.
منابع مشابه
Assessing the factors affecting liquidity by focusing on the capital adequacy ratio of the banking network and its asymmetric effects
Liquidity , as the most important variable of the money market , has a significant role in economic performance from various aspects and therefore it is important to identify the factors affecting liquidity. Considering that one of the channels to increase liquidity is loans paid by the banking network and the effective role of capital adequacy ratio in the payment of bank loans, in the present...
متن کاملDesign of a new asymmetric waveguide in InP-Based multi-quantum well laser
Today, electron leakage in InP-based separate confinement laser diode has a serious effect on device performance. Control of electron leakage current is the aim of many studies in semiconductor laser industry. In this study, for the first time, a new asymmetric waveguide structure with n-interlayer for a 1.325 μm InP-based laser diode with InGaAsP multi-quantum well is proposed and theoreticall...
متن کاملNumerical Study on Resistance of a Bulk Carrier Vessel Using CFD Method
Bulk carriers have an important role in international maritime transport. In this paper, we carried out a numerical study on a model of bulk carrier vessel and calculated total resistance of the model. A model of a bulk carrier vessel with length of 2.76 m, breadth of 0.403 m and draught of 0.173 m was selected for numerical modeling. Numerical work was done by commercial CFD software ANSY...
متن کاملHeat Transfer on Peristaltic Transport with Slip Condition in an Asymmetric Porous Channel (TECHNICAL NOTE)
Simultaneous effects of slip and heat transfer on peristaltic transport of an incompressible electrically conducting viscous fluid in an asymmetric channel is studied under the assumptions of long wavelength and low Reynold number .The asymmetry is produced by choosing the peristaltic wave train on the walls to have different amplitudes and phase.Exect solutions for stream function,velocity ...
متن کاملImproving the Thermal Characteristics of Semiconductor Lasers Using a New Asymmetric Waveguide Structure
Self-heating leads to a temperature rise of the laser diode and limits the output power and efficiency due to increased loss and decreased differential gain. To control device self-heating, it is required to design the laser structure with a low optical loss, while the heat flux must spread out of the device efficiently. In this study, a new asymmetric waveguide design is proposed and th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Biochimica et biophysica acta
دوره 436 1 شماره
صفحات -
تاریخ انتشار 1976